Tau-targeting antibody therapies: too late, wrong epitope or wrong target?

Inotropic therapy is unsuccessful: wrong conceptual target or wrong therapeutic tools?

Since a depressed contractility has long been considered the primary defect in patients with heart failure, the use of inotropic agents has been regarded as a logical approach to treat this syndrome. Despite this conceptual framework, these drugs have not yet established themselves in the treatment of chronic heart failure and their long-term use was associated with an excessive mortality while...

Wrong-side/wrong-site, wrong-procedure, and wrong-patient adverse events: Are they preventable?

HYPOTHESIS Wrong-side/wrong-site, wrong-procedure, and wrong-patient adverse events (WSPEs) are devastating, unacceptable, and often result in litigation, but their frequency and root causes are unknown. Wrong-side/wrong-site, wrong-procedure, and wrong-patient events are likely more common than realized, with little evidence that current prevention practice is adequate. DESIGN Analysis of se...

Bevacizumab (Avastin) for retinopathy of prematurity: wrong dose, wrong drug, or both?

I nterest in and controversy over the use of bevacizumab (Avastin; Genentech/Roche, South San Francisco, CA) for the treatment of retinopathy of prematurity (ROP) have increased dramatically after the Bevacizumab Eliminates the Angiogenic Threat of Retinopathy of Prematurity (BEAT-ROP) study. Off-label bevacizumab has been used extensively for age-related macular degeneration (AMD) for more tha...

The disappointing performance of the new "Magnetic Sphincters": a wrong idea or a wrong realization?

In these last years devices based on magnetic activity have been proposed and marketed to reinforce weak gut sphincters, as the lower esophageal sphincter (LES), to prevent gastroesophageal reflux (GER) [1], and the anal sphincter to prevent feca l incontinence [2], with the purpose of replacing previous surgical solutions. However, these artificial sphincters have revealed some drawbacks and i...

Wrong-site errors as likely outside OR.